Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.
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Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International
Abstract Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. The angle of repose of powder blend was determined by fixed height funnel method. December 20, Published: However, this technique cannot be applied to compactts dose poorly soluble drugs is because ,iquisolid the high amount of liquid vehicle needed.
At higher values the greater amount of carrier may overcome to some extent the flow properties of powder. In the formulation development process solubility of active compound is one of the main criteria considered before deciding the dosage form. From the results of different batches prepared by three different carriers shown in Table 6it was found that Neusilin proved to be the superior carrier than others.
It can be concluded from this study that novel porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose drugs like CBZ. Supernatant was filtered through membrane liquisllid using 0. Liquissolid of which the recent research focus on liquisolid compact technique or powdered solution technique as one of the successful tool to achieve the goal.
Formulations containing Fujicalin and Neusilin showed improved flowability in comparison to Avicel PH FTIR spectroscopy helps to determine any chemical interaction between drug and excipients used in formulation.
All prepared tablets complied with the pharmacopoeial required specifications for the weight variation and content uniformity tests. As highest compwcts release rates are observed with liquisolid compact system and this system may be optimized by selection of the liquid vehicle and the carrier and coating materials.
The aim of present investigation was to prepare liquisolid compacts of high dose water insoluble drug, carbamazepine CBZ using novel porous carriers such as Neusilin and Fujicalin in order to improve its dissolution rate and reduce the tablet weight. Olmesartan medoxomil was received as a gift sample from Alembic Pharma Ltd. Amongst carriers used Fujicalin and Neusilin were found vompacts be more effective carrier materials for liquid adsorption.
Spireas S Liquisolid systems and methods of preparing same. The liqusiolid strength of the tablet was also sufficient. View at Google Scholar. Formulation FA3 containing Fujicalin exhibited lower mean dissolution time and higher dissolution efficiency than all other formulations including marketed tablet. Pharmaceutical Sciences Journals Ann Jose ankara escort.
The solubility is an liqisolid factor in liquisolid systems, as higher solubility of drug in liquid vehicle can lead to higher dissolution rates since the drug will be more molecularly dispersed and more surface compacys drug will be exposed to the dissolution media. Cumulative percent drug release was plotted as a function of time, and percent drug release in 5 minutes was calculated.
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Journal of Drug Delivery. The weight of formulations containing Neusilin and Fujicalin ranged in between 0. The highest liquid factor was obtained for Neusilin, and accordingly, the amount of carrier was lower than other formulations.
This could be probably due to the presence of higher amounts of silica in and lower in. The prepared liquisolid compacts were evaluated and compared for thickness, diameter, weight variation, uniformity of content, hardness, friability, disintegration and in vitro dissolution. International Journal of ChemTech Research 2: Liquisolid compacts are acceptably flowing and compressible powder forms of liquid medications.
The three principal suggested mechanisms include an increased surface area of drug particles, an increased aqueous solubility, and an improved wettability of the drug particles. IR spectrum of pure Olmesartan medoxomil shown in Figure 4 aan absorption band was observed, peaks A lesser amount of Neusilin was required to adsorb the same amount of liquid vehicle than Avicel and Fujicalin, which lowered the weight of tablet.
Authors and affiliation s: Several techniques have been reported to improve drug solubility, among which the liquisolid technology is one of the most promising approaches. Fujicalin and Neusilin are used as carrier materials instead of Avicel, the liquid adsorption capacity increases by many folds.
The solubility of several therapeutic agents is an important technical challenge in formulating as a suitable dosage form efficient its drug delivery [ 12 ]. Patil J Liquisolid Compact Technique: Composition of liquids solid compacts batches is shown in Table 1. Solubility data of drug olmesartan medoxomil in various liquid vehicles is shown in Table 2.
A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties. December 24, Citation: The was then used to decide the optimum amount of carrier and coating liquidolid required to ensure dry-looking, free-flowing and compactible powdered systems.
Then, coating material was carefully added and mixed until mortar contents start to look dry. The excipient and coating material are to be taken into definite ratios so as to retain the accepted amount of liquid to be converted into solid. Several researchers have shown that the liquisolid technique is the most promising method for promoting dissolution rate of poorly water-soluble drugs [ 3 — 5 ].